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Clinical Trials

"An Open-label, Pilot Study evaluating the Safety and Efficacy of Converting from Calcineurin Inhibitors to Rapamune in established Renal Allograft Recipients on Maintenance Therapy with Moderate Renal Insufficiency."
Funded by Wyeth Ayerst Pharmaceutical Company.

" A prospective, randomized, multicenter trial of early corticosteroid cessation vs. long term maintenance corticosteroid therapy in primary renal allograft recipients treatment with tacrolimus and mycophenolate mofetil."
Funded by Fujisawa Pharmaceuticals.

" A Prospective, pilot study of early corticosteroid cessation with Zenapax, Prograf, Cellcept, and Rapamune in High Immunologic Risk Renal Transplant Recipients."
Funded by Roche Laboratories.

" A Prospective Pilot Study of Corticosteroid Avoidance with Prograf, Cellcept and Rapamune that Avoids Induction Therapy in Renal Transplant Patients."
Funded by Wyeth Ayerst Pharmaceutical Company.

" An open-label study to evaluate the safety and efficacy of early (5 day) steroid cessation in de novo renal allograft recipients treated with Simulect induction and Prograf in combination with Rapamune."
Funded by Wyeth Ayerst Pharmaceutical Company.

" A multicenter, randomized, partially-blinded study of the safety and efficacy of FTY720 combined with corticosteroids and full or reduced dose Neoral in de novo adult renal transplant recipients."
Funded by Novartis Pharmaceutical Company.

" Corticosteroid-free, Calcineurin-sparing Immunosuppression Protocol for HLA-Identical Living Donor Renal Transplant Recipients."
Funded by Roche Laboratories.

" A randomized, open-label, comparative evaluation of conversion from calcineurin inhibitors to sirolimus versus continued use of calcineurin inhibitors in renal allograft recipients."
Funded by Wyeth Ayerst Pharmaceutical Company.

" Open-Label, Randomized, Prospective Multicenter Study to Compare the Efficacy and Safety among Three Immunosuppressant Treatment Regimens in Patients Receiving a Liver Transplant for End-Stage Liver Disease Caused by Chronic Hepatitis C Infection."
Funded by Roche Laboratories.

" Rapamune Outcomes Assessment Registry."
Funded by Wyeth Ayerst Pharmaceutical Company.

" Pharmacokinetic and Pharmacodynamic evaluation of open-label, comparative trial of two daclizumab dosing strategies versus no induction treatment in combination with tacrolimus, mycophenolate mofetil, and steroids for the prevention of acute allograft rejection in simultaneous kidney/pancreas transplant recipients."
Funded by Roche Laboratories.

" A Phase 2, Randomized Multicenter, double-blind safety study of ISA 247 and Cyclosporine in post renal Transplant Patients."
Funded by Isotechnika.

" A Single Center, Pilot Study of Corticosteroid Discontinuation in Liver Transplant Recipients Utilizing a Tacrolimus/Mycophenolate Mofetil based Maintenance Immunosuppression Protocol."
Funded by Fujisawa Pharmaceuticals.

" The Effect of Immunonutrients and Monolayer Integrity on the Transcriptional Control of Enterocyte Defenses."
Shriners of North America.

" Comparison of two vascular access grafts and the role of arginine and Canola Oil to Prevent Graft Complications."
Funded by Atrium Medical Corporation.

" Clinical Islet Transplantation for Hypoglycemic Unawareness and glycemic control in humans."
Funded by University Hospital/Health Alliance.

If you are interested in participating in one of these clinical trials, please contact:

E. Steve Woodle, M.D.
Chief, Division of Transplantation
(513) 558-6001
WOODLEES@UCMAIL.UC.EDU

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