Jeffrey J. Sussman, M.D.
Associate Professor of Surgery
Interim Chief, Division of Surgical Oncology
Department of Surgery
University of Cincinnati, Ohio
Veteran’s Administration, Cincinnati, Ohio
Education:
B.S., Biomedical Sciences
University of California, Riverside, California
(senior year undergraduate and first year medical were concurrent)
1980-1984
M.D., UCLA School of Medicine
Los Angeles, California
1983-1986, 1987-1988
General Surgery Residency
University of Michigan Hospitals
Ann Arbor, Michigan
1988-1995
Surgical Critical Care Fellow
University of Michigan Hospitals
Ann Arbor, Michigan
1991-1992
Surgical Oncology Research Fellow
University of Michigan Hospitals
Ann Arbor, Michigan
1991-1993
Surgical Oncology Clinical Fellowship / Junior Faculty Associate
Department of Surgical Oncology
M.D. Anderson Cancer Center
Houston, Texas
1995-1997
Physician Leadership Program
University of Cincinnati/Humana
Cincinnati, Ohio
2007-2008
Academic Positions:
Assistant Professor of Surgery
Division of Surgical Oncology
Department of Surgery
University of Cincinnati
Cincinnati, Ohio
1997-2007
Associate Professor of Surgery
Division of Surgical Oncology
Department of Surgery
University of Cincinnati
Cincinnati, Ohio
2007-present
Interim Division Chief, Surgical Oncology
Department of Surgery
University of Cincinnati
Cincinnati, Ohio
2007-present
Staff Surgeon
Department of Surgery
Veteran’s Affairs Medical Center
Cincinnati, Ohio
1997-present
Certification and Licensure:
American Board of Surgery Certification: General Surgery, 1996; Recertification, 2004
Medical Licensure: Ohio, 1997-present
Certified by American College of Surgeons in Advanced Ultrasound-Thyroid/Parathyroid, October 2006
Honors:
University of California Regents Scholar, 1980-1984
CRC Press Freshman Chemistry Achievement Award, 1981
Phi Beta Kappa, 1983
University of California, Riverside Graduation, Highest Honors, 1984
Carl Fuglie Scholarship Award in Biomedical Sciences, 1984
Howard Hughes/NIH Research Scholar, 1986-87
Alpha Omega Alpha, 1988
Alpha Omega Alpha Research Award (first place), 1988
Emil Bogen Research Prize, UCLA 1988
Robert Danto Cancer Research Memorial Award, American College of Surgeons,
Michigan Chapter, 1993
James W. Crudup Research Award, University of Michigan, 1995
Coller Society Travel Grant Recipient, 1995
Berlex Oncology Clinical Trial Design/Statistics, 1996
Central Surgical Association Foundation Award, 1999
Business Courier Health Care Hero Nominee, 2000, 2001
Elliot Osserman Award, 2007
Best Doctors in America Survey 2007-2008
Medical Organization Membership:
American College of Surgeons, Fellow
American College of Surgery Oncology Group, Melanoma committee
American Society of Clinical Oncology
Association of VA Surgeons
Central Surgical Association
Cincinnati Academy of Medicine
Cincinnati Surgical Society
Commission on Cancer, Cancer Liaison Physician VAMC
Mont Reid Surgical Society
North American Surgical Oncology Group
Ohio Medical Association
Society of Surgical Oncology
Society of University Surgeons
Southwest Oncology Group, Melanoma, Sarcoma and Surgery subcommittees
Teaching Activities:
Instructor, Advanced Cardiac Life Support, 1990-1994
Instructor, Advanced Trauma Life Support, 1990-1995
General Surgery Resident Advisor, 1998-2006
Medical Student Advisor, 1999-2000
Medical Student Cost Effectiveness Project Mentor, 2000
Interactive Student Teaching, 3rd yr surgical medical students, Spleen/Lymphoma, q 8 weeks, 1997-2003
Interactive Student Teaching, 3rd yr surgical medical students, adrenal, q 8 weeks, 2003
Interactive Student Teaching, 3rd yr surgical medical students, sarcoma, q 8 weeks, 1997-2003
Interactive Student Teaching, 3rd yr surgical medical students, melanoma, q 8 weeks, 2002-2006
Faculty of Medical Student Oncology Elective, weekly, 2000-2006
City-wide Resident Mock Orals Examination, 2006
Administrative Activities:
University of Michigan Patient Care Information System Selection Committee, 1992-1993
Cincinnati VAMC Co-Chairman Cancer Care Committee, 1998-2001
Internet Web Site Subcommittee, Department of Surgery, 1999-2000
Contract Review Subcommittee, Department of Surgery, 1999-2001
Scientific Review Committee, Barrett Cancer Center, 2000-2001
Finance Committee, Department of Surgery, 2001-2006
Department of Surgery Resident Education Committee, 2002-2006
VA Bio-safety Committee, 2003-2004
Board of Governors, South Western Oncology Group, 2004-2006
Associate Examiner, American Board of Surgery, 2004
Israel Cancer Research Fund, Study Section Panel B Reviewer, 2005-2007
ICRF Scientific Advisory Board, 2007-
Netwellness Expert Panel: Thyroid diseases, 2006-
Search Committee, Vascular Division Chief, Department of Surgery, 2006
Search Committee, Heme-Oncology Division Director, Dept of Internal Medicine, 2007
Chair, Cancer Care Performance Improvement Committee, 2007-
Barrett Cancer Center Operations Committee, 2007-
Chair, Cancer Center Medical Directors Committee, 2007-
UC/Humana Physician Leadership Program, 2007-2008
Clinical Care Administration:
Principal Investigator, Sunbelt Melanoma Trial, University of Cincinnati site, 1997-2004
Multidisciplinary Melanoma Core Faculty, 1998-2006
Principal Investigator, ACOS-OG Melanoma Limb Perfusion Trial Z020, University of Cincinnati site, 2000-2004
Surgical Principal Investigator, SWOG Melacine Adjuvant Trial for HLA A2/C3 Patients, 2003-2004
Melanoma Care Consortium, National Faculty, 2004-2006
Principal Investigator, Multicenter Selective Lymphadenectomy Trial-II, UC Site, 2005-2006
Editorial Activities:
Ad hoc reviewer, Cancer Research, Cancer, Annals of Surgical Oncology, Journal of Surgical Oncology, Journal of Clinical Oncology, 1999-2006
Research Grants:
Howard Hughes Medical Institute
Research Scholars Program
1986-1987
National Research Service Award
NIH Postdoctoral Training Fellowship (T32 CA09672)
Surgical Oncology
1991-1993
American Cancer Society
Postdoctoral Training Grant #PRTF-148
T Cell Receptor Vb Chain Usage in Anti-Tumor Effector T Cells
1992-1993
American Cancer Society
Institutional Grant #189
Cytokine/tumor vaccine-primed draining lymph node cells: Phenotype and activity after ex-vivo activation and expansion
PI: Sussman, JJ
1997-1998
Faculty Development Award
Immunotherapy External Site Visits
PI: Sussman, JJ
1998-1999
University Research Council Grant
Tumor Induced Immunosuppression in a Poorly Immunogenic Murine Melanoma
PI: Sussman, JJ
1998-1999
Central Surgical Association
Modulation of the Type 1 / Type 2 Immune Response to Improve Cancer Immunotherapy
PI: Sussman, JJ
1999-2000
Ohio Cancer Research Associates
Immune Response Modulation Improves Cancer Immunotherapy
PI: Sussman, JJ
1999-2001
VA VISN 10 Research Initiative Program
Immune Response Modulation to Improve Cancer Immune therapy
PI: Sussman, JJ
1999-2000
VA Advanced Career Development Award
Immune Response Modulation to Improve Cancer Immune therapy
PI: Sussman, JJ
2000-2003
Ruth Lyons / Cancer Challenge Program
Establishment of a Cellular Adoptive Immunotherapy Laboratory
PI: Sussman, JJ and Lowy, AM
2000-2001
Dean’s Discovery Fund Award
Establishment of a Cellular Adoptive Immunotherapy Laboratory
PI: Sussman, JJ
2004-2005
Presentations (Selected):
"Stimulation of murine T cell hybridomas with anti-Thy-1 monoclonal antibodies results in IL-2 production and inhibition of growth" -- Federation of American Societies for Experimental Biology, Washington DC, 1987, poster presentation.
"Systemic transfer of superantigen activated T cells leads to the regression of experimental brain tumors in mice" -- American College of Surgeons, Clinical Congress, Surgical Forum, San Francisco, CA, 1993.
"Systemic T cell adoptive immunotherapy of experimental brain tumors" -- American College of Surgeons, Michigan Chapter Resident-Surgeons Day, Grand Rapids, MI, 1993.
"Eradication of murine intracranial tumors by systemic T cell immunotherapy" -- Immunotherapy of Cancer Keystone Symposia, Taos, NM, 1993.
"Systemic T cell adoptive immunotherapy of experimental brain tumors" -- American Association of Immunologists, Denver, CO, 1993.
"Short-term continuous infusion of IUDR produces potentially radiosensitizing incorporation in soft tissue sarcomas" -- American Society of Clinical Oncology, Orlando, FL, 1993.
"Pregnancy and Cancer" -- M.D. Anderson Grand Rounds, Houston, TX, 1996.
"Immunotherapy and Melanoma" -- M.D. Anderson Grand Rounds, Houston, TX, 1997.
"Lymphatic Mapping and Sentinel Node Identification in Melanoma and Breast Cancer" -- Medical Oncology Grand Rounds, 9/1997; Radiation Oncology Grand Rounds 8/1998 Cincinnati, OH.
"Breast Cancer Lymphatic Mapping and Sentinel Node Identification " -- Christ Hospital Winter Conference, St. Thomas, USVI, 2/1998.
"Melanoma Lymphatic Mapping and Sentinel Node Identification " -- Schering sponsored Cincinnati, OH, Community Physician Outreach, 2/98, 4/98, 5/98, 8/98, 4/99.
“Advances in Melanoma” -- General Surgery Grand Rounds 3/1998, Dermatology Grand Rounds, 7/1998, Head & Neck Surgery Grand Rounds, 12/1998, and Plastic Surgery Grand Rounds, 2/1999, Cincinnati, OH.
“Childhood Melanoma” -- Tumor board, 4/1998, Children’s Hospital, University of Cincinnati, OH, slide presentation.
“Moles and Melanoma” -- Public Education: Radio stations WVXU, 8/1998; WKFI, 8/1998; Wellness Community, 9/1998, Cincinnati, OH.
Moderator for “Lymphatic Mapping for Breast Cancer and Melanoma,” Satellite Course, 1998 Cincinnati, OH.
Guest Faculty, Lymphatic Mapping and Sentinel Node Biopsy Course, 12/10/1998, 6/3/1999, Institute for Research and Education, Minneapolis, MN.
“Hyperthermic Isolated Limb Perfusion,” Good Samaritan Hospital, Surgery Grand Rounds, 10/1999, Cincinnati, OH.
“Nodal Management”-- Melanoma Update for the Millennium, 10/1999, Cincinnati, OH.
“Sun Protection/Childhood Melanoma” Public Education TV station WLW 5/2000, Cincinnati, OH.
“Hyperthermic Chemoperfusion” Good Samaritan Grand Rounds, 12/8/2000, Cincinnati, OH.
“Advances in Melanoma Management” Medical Oncology Grand Rounds, 11/3/2000, Cincinnati, OH.
“Advances in Melanoma Management” Plastic Surgery Grand Rounds, 8/8/2001, Cincinnati, OH.
“Node Management in Melanoma” General Surgery Grand Rounds, 3/6/2002, Cincinnati, OH.
Breast Sentinel Node Workshop, St Lukes Hospital, 4/5/2002
“Immunotherapy of Cancer” General Surgery Grand Rounds, 1/2003, Cincinnati, OH.
“Diagnosis and Treatment Benign Liver Masses” Primary Care Update on Cancer Seminar, 5/2004. Cincinnati, OH.
“Breast Cancer Update” VA Women’s Health Care Update, 11/2004. Columbus, OH.
Melanoma Awareness Program, 2002-2007, Cincinnati, OH; Dayton OH, Kettering OH, Fort Wayne, IN., Troy, OH.
“Update Parathyroid Surgery”, 10/2006, UCS Symposium, Mason, OH.
“Pancreatic Cancer Surgery-Is there a Standard?” 2nd Annual Esophogeal/Pancreatic Cancer Symposium, 11/2006, Cincinnati, OH.
BIBLIOGRAPHY
Published Articles:
1. Sussman JJ, Bonifacino JS, Lippincott-Schwartz J, Weisman AM, Saito T, Klausner RD, Ashwell JD: Failure to Synthesize the T Cell CD3-Zeta Chain: Structure and Function of a Partial T Cell Receptor Complex. Cell. 52(1):85-95, 1988.
2. Sussman JJ, Mercep M, Saito T, Germain RN, Bonvini E, Ashwell JD: Dissociation of Phosphoinositide Hydrolysis and Ca2+ Fluxes from the Biological Responses of a T Cell Hybridoma. Nature. 334(6183):625-8, 1988.
3. Sussman JJ, Saito T, Shevach EM, Germain RN, Ashwell JD: Thy-1- and Ly-6-Mediated Lymphokine Production and Growth Inhibition of a T Cell Hybridoma Require Co-Expression of the T Cell Antigen Receptor Complex. J. Immunol. 140(8):2520-6, 1988.
4. Bonifacino JS, Mercep M, Sussman JJ, Klausner RD, Ashwell JD: The T-Cell Antigen Receptor: A Complex Signal-Transducing Molecule. Int Symp Princess Takamatsu Cancer Res Fund. 19:87-104, 1988.
5. Saito T, Sussman JJ, Ashwell JD, Germain RN: Marked Differences in the Efficiency of Expression of Distinct Alpha Beta T Cell Receptor Heterodimers. J. Immunol. 143(10):3379-84, 1989. [erratum: 144(7):2848, 1990]
6. Volarevic S, Burns CM, Sussman JJ, Ashwell JD: Intimate Association of Thy-1 and the T Cell Antigen Receptor with the CD45 Tyrosine Phosphatase. Proc. Natl. Acad. Sci. USA. 87(18):7085-9, 1990.
7. Shu S, Sussman JJ, Chang AE: In Vivo Antitumor Efficacy of Tumor-Draining Lymph Node Cells Activated with Nonspecific T-Cell Reagents. J. Immunother. 14:279-85, 1993.
8. Sussman JJ, Chang AE, Shu S: Systemic Transfer of Superantigen-Activated T Cells Leads to the Regression of Experimental Brain Tumors in Mice. Surgical Forum XLIV:477-9, 1993.
9. Shu S, Krinock RA, Matsumura T, Sussman JJ, Fox BA, Chang AE, Terman DS: Stimulation of Tumor-Draining Lymph Node Cells with Superantigenic Staphylococcal Toxins Leads to the Generation of Tumor-Specific Effector T Cells. J. Immunol. 152:1277-88, 1994.
10. Matsumura T, Sussman JJ, Krinock RA, Chang AE, Shu S: Characteristics and In Vivo Homing of Long-Term T Cell Lines and Clones Derived from Tumor-Draining Lymph Nodes. Cancer Res. 54:2744-50, 1994.
11. Sussman JJ, Shu S, Sondak VK, Chang AE: Activation of T Lymphocytes for the Adoptive Immunotherapy of Cancer. Ann. Surg. Oncol. 1(4):296-306, 1994.
12. Wahl WL, Sussman JJ, Shu S, Chang AE: Adoptive Immunotherapy of Murine Intracerebral Tumors with Anti-CD3/IL-2 Activated Tumor-Draining Lymph Node Cells. J. Immunother. 13:242-250, 1994.
13. Robertson JM, Sondak VK, Weiss SA, Sussman JJ, Chang AE, Lawrence TS: Preoperative Radiation Therapy and Iododeoxyuridine for Large Retroperitoneal Sarcomas. Int. J. Rad. Oncol. Biol. and Phys. 31:87-92, 1995.
14. Sussman JJ, Wahl WL, Chang AE, Shu S: Unique Characteristics Associated with Systemic Adoptive Immunotherapy of Experimental Intracerebral Tumors. J. Immunother. 18(1):35-44, 1995.
15. Sondak VK, Robertson JM, Sussman JJ, Saran PA, Chang AE, Lawrence TS: Preoperative Iododeoxyuridine and Radiation for Large Soft Tissue Sarcomas: Clinical Results with Five-year Follow-up. Annals of Surgical Oncology, 5(2): 106-112. 1998.
16. Heaton KM, Sussman JJ, Gershenwald JE, Lee JE, Reintgen DS, Mansfield PF, Ross MI: Surgical Margins and Prognostic Factors in Thick (>4mm) Primary Melanoma. Annals of Surgical Oncology, 5(2): 322-327. 1998.
17. Anderson CM, Buzaid AC, Sussman JJ, Lee J, Ali-Osman F, Braunschweiger PG, Plager, C, Bedekian A, Papadopuolos n, Eton O, Legha S, Grimm EA,: Nitric Oxide and Neopterin Levels and clinical Response in Stage III Melanoma Patients Receiving Concurrent Biochemotherapy. Melanoma Research, 8(2):149-55. 1998
18. Dackiw APB, Sussman JJ, Stanford P, Hoff A, Gagel RF, Evans DB, Lee JE: Relative Contributions of Technitium 99M Sestamibi Scintigraphy, Intraoperative Gamma Probe Detection and the Rapid PTH Assay to the Surgical Management of Hyperparathyroidism. Archives of Surgery, 135(5):550-5. 2000.
19. Sarnaik AA, Sussman JJ, Ahmad SA, Lowy AM. Technology of Intraperitoneal Chemotherapy Administration: A Survey of Techniques with a Review of Morbidity and Mortality. Surgical Oncology Clinics of North America. WB Saunders, vol 12 (3), pp 849-864, 2003
20. Ahmad SA, Kim J, Sussman JJ, Soldano DA, Pennington LJ, James LE, Lowy AM. Reduced morbidity following cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion. Annals of Surgical Oncology,11(4): 387-392. 2004.
21. McMasters KM, Noyes RD, Reintgen DS, Goydos JS, Beitsch PD, Davidson BS, Sussman JJ, Gershenwald JE, Ross MI; Sunbelt Melanoma Trial. Lessons learned from the Sunbelt Melanoma Trial. J Surg Oncol. 2004 Jul 1;86(4):212-23.
22. Sussman, JJ, Parihar R, Winstead K, Finkelman, FD. Prolonged Culture of Vaccine Primed Lymphocytes Results in Decreased Anti-Tumor Killing and Change in Cytokine Secretion. Cancer Research, 64(24): 9124-9130 2004.
23. Lee PK, Sussman JJ 53 year old Melanoma on Back. Melanoma Care Options, Volume 6, July 2005.
24. Hershko DD, Robb BW, Lowy AM, Ahmad SA, Ramadas GH, Pennington LJ, Soldano DA, Sussman JJ. High Incidence of Positive Sentinel Lymph Nodes Identified in Thin Melanoma Patients. J Surg Oncol. 93(4):279-85, 2006.
25. Scoggins CR, Ross MI, Reintgen DS, Noyes D, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Davidson BS, Sussman JJ, Edwards MJ, Martin CG, Conrad A, Albrecht J, Mc,asters KM. A Prospective Multi-Institutional Study of Reverse Transcriptase Polymerase Reaction for Molecular Staging of Melanoma J Clin Oncol, 24(18):2849-57, 2006.
26. Cornett WR, Fraker DL, Ross MI, Briele HA, Bodie AW, Noyes RD, Sussman JJ, McCall JE, Herndon JE, Tyler DS. Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020. J Clin Oncol Sept. 24(25): 4196-201, 2006.
27. Hugo E, Brandenbourgh T, Comstock C, Gersin K, Sussman JJ, Ben-Jonathan N. LS14: A Novel Human Adipocyte Cell Line that Produces Prolactin. Endocrinology. Jan;147(1):306-13, 2006.
28. Scoggins CR, Ross MI, Reintgen DS, Noyes D, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Sussman JJ, Edwards MJ, Chagpar AB, Martin RCG, Stromberg AJ, Hagendoorn L, McMasters KM Gender Related Differences in Outcome for Melanoma Patients. Ann Surg 243:693-700, 2006.
29. Mammen JM, James LE, Molloy M, Williams A, Wray CJ, Sussman JJ. The relationship of lymph node dissection and colon cancer survival in the Veterans Affairs Central Cancer Registry.. Am J Surg. 194(3):349-54, 2007
30. Mammem, JMV, James LE, Ahmad, S, Sussman JJ, The Relationship of Lymph NodeStatus and Extrahepatic Cholagiocarcinoma Survival in the Veterans Affairs Central Cancer Registry, submitted Am J Surgery, 2007.
31. Nair R, McIntyre B, Lowy AM, Sussman JJ, Matthews JB, Ahmad SA. A novel technique for the management of refractory pancreatic fistula in press Sugery 2007.
Chapters:
1. DeLucia, A, Magee, JC, Shanley, CJ, Simeone, DM, Sussman JJ, Wahl, WL. Review for Surgery: Scientific Principles and Practice. Greenfield, LJ, Mulholland, MW, Oldham, KT, Zelenock, GB (Eds.) J.B.Lippincott, Philadelphia, 1993.
2. Sussman JJ, Ellis, LM. Current Therapy for Hepatic Metastases, In: Current Hepatology; Volume 17. Gitnick, G (ed) Mosby, Chicago, p. 195-220, 1997.
3. Gershenwald JE, Sussman JJ, Lee JE. Melanoma (chapter 3), In: The M. D. Anderson Surgical Oncology Handbook, second edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 1999.
4. Bold RJ, Sussman JJ, Tyler DS. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia (chapter 14), In: The M. D. Anderson Surgical Oncology Handbook, second edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 1999.
5. Sussman JJ. Adoptive Cellular Therapy for Cancer, In: Current Perspectives in Cellular Therapy 2002. Szczepirkowski, ZM and Snyder, EL (Eds.), American Association of Blood Banks, 2001.
6. Barnett CC, , Sussman JJ, Gershenwald JE. Melanoma (chapter 3), In: The M. D. Anderson Surgical Oncology Handbook, Third edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 2003.
7. Lenert JT, Bold RJ, Sussman JJ, Tyler DS. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia (chapter 14), In: The M. D. Anderson Surgical Oncology Handbook, Third edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 2003.
8. Sussman JJ, Surgical Emergencies in the Cancer Patient. Surgery: Basic Science and Clinical Evidence, 2nd edition, ed. JA Norton, et al, Springer-Verlag (submitted)
9. Lenert JT, Bold RJ, Sussman JJ, Tyler DS. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia (chapter 14), In: The M. D. Anderson Surgical Oncology Handbook, Fourth edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 2006.
10. Sussman JJ, Surgical Emergencies in the Cancer Patient. Essentials of Surgical Oncology. Editors: Sondak VK, Sabel M, and Sussman JJ. Elsevier Science/MOSBY, Philidelphia, 2007
11. Sussman JJ, Surgery for Advanced Cancer. Essentials of Surgical Oncology. Editors: Sondak VK, Sabel M, and Sussman JJ. Elsevier Science/MOSBY, Philidelphia, 2007
Books:
1. Essentials of Surgical Oncology. Editors: Sondak VK, Sabel M, and Sussman JJ. Elsevier Science/MOSBY, Philadelphia, 2007.