Jeffrey J. Sussman, M.D.

Associate Professor of Surgery
Interim Chief, Division of Surgical Oncology
Department of Surgery
University of Cincinnati, Ohio
Veteran’s Administration, Cincinnati, Ohio


Education:

B.S., Biomedical Sciences

University of California, Riverside, California
(senior year undergraduate and first year medical were concurrent)

1980-1984

M.D., UCLA School of Medicine

Los Angeles, California

1983-1986, 1987-1988

 

General Surgery Residency

University of Michigan Hospitals

Ann Arbor, Michigan

1988-1995

Surgical Critical Care Fellow

University of Michigan Hospitals

Ann Arbor, Michigan

1991-1992

Surgical Oncology Research Fellow

University of Michigan Hospitals

Ann Arbor, Michigan

1991-1993

Surgical Oncology Clinical Fellowship / Junior Faculty Associate

Department of Surgical Oncology

M.D. Anderson Cancer Center

Houston, Texas

1995-1997

Physician Leadership Program

University of Cincinnati/Humana

Cincinnati, Ohio

2007-2008

 

Academic Positions:

Assistant Professor of Surgery
Division of Surgical Oncology
Department of Surgery
University of Cincinnati

Cincinnati, Ohio

1997-2007

Associate Professor of Surgery
Division of Surgical Oncology
Department of Surgery
University of Cincinnati

Cincinnati, Ohio

2007-present

Interim Division Chief, Surgical Oncology

Department of Surgery
University of Cincinnati

Cincinnati, Ohio

2007-present

Staff Surgeon
Department of Surgery
Veteran’s Affairs Medical Center

Cincinnati, Ohio

1997-present

 

Certification and Licensure:

American Board of Surgery Certification:  General Surgery, 1996; Recertification, 2004

Medical Licensure: Ohio, 1997-present

Certified by American College of Surgeons in Advanced Ultrasound-Thyroid/Parathyroid, October 2006

 

Honors:

University of California Regents Scholar, 1980-1984
CRC Press Freshman Chemistry Achievement Award, 1981
Phi Beta Kappa, 1983
University of California, Riverside Graduation, Highest Honors, 1984
Carl Fuglie Scholarship Award in Biomedical Sciences, 1984
Howard Hughes/NIH Research Scholar, 1986-87
Alpha Omega Alpha, 1988
Alpha Omega Alpha Research Award (first place), 1988
Emil Bogen Research Prize, UCLA 1988
Robert Danto Cancer Research Memorial Award, American College of Surgeons, Michigan Chapter, 1993
James W. Crudup Research Award, University of Michigan, 1995
Coller Society Travel Grant Recipient, 1995
Berlex Oncology Clinical Trial Design/Statistics, 1996
Central Surgical Association Foundation Award, 1999
Business Courier Health Care Hero Nominee, 2000, 2001

Elliot Osserman Award, 2007

Best Doctors in America Survey 2007-2008

 


Medical Organization Membership:

American College of Surgeons, Fellow
American College of Surgery Oncology Group, Melanoma committee
American Society of Clinical Oncology
Association of VA Surgeons
Central Surgical Association
Cincinnati Academy of Medicine
Cincinnati Surgical Society
Commission on Cancer, Cancer Liaison Physician VAMC
Mont Reid Surgical Society
North American Surgical Oncology Group
Ohio Medical Association
Society of Surgical Oncology

Society of University Surgeons

Southwest Oncology Group, Melanoma, Sarcoma and Surgery subcommittees

Teaching Activities:

Instructor, Advanced Cardiac Life Support, 1990-1994

Instructor, Advanced Trauma Life Support, 1990-1995

General Surgery Resident Advisor, 1998-2006

Medical Student Advisor, 1999-2000

Medical Student Cost Effectiveness Project Mentor, 2000

Interactive Student Teaching, 3rd yr surgical medical students, Spleen/Lymphoma, q 8 weeks, 1997-2003

Interactive Student Teaching, 3rd yr surgical medical students, adrenal, q 8 weeks, 2003

Interactive Student Teaching, 3rd yr surgical medical students, sarcoma, q 8 weeks, 1997-2003

Interactive Student Teaching, 3rd yr surgical medical students, melanoma, q 8 weeks, 2002-2006

Faculty of Medical Student Oncology Elective, weekly, 2000-2006

City-wide Resident Mock Orals Examination, 2006

Administrative Activities:

University of Michigan Patient Care Information System Selection Committee, 1992-1993

Cincinnati VAMC Co-Chairman Cancer Care Committee, 1998-2001

Internet Web Site Subcommittee, Department of Surgery, 1999-2000

Contract Review Subcommittee, Department of Surgery, 1999-2001

Scientific Review Committee, Barrett Cancer Center, 2000-2001

Finance Committee, Department of Surgery, 2001-2006

Department of Surgery Resident Education Committee, 2002-2006

VA Bio-safety Committee, 2003-2004

Board of Governors, South Western Oncology Group, 2004-2006

Associate Examiner, American Board of Surgery, 2004

Israel Cancer Research Fund, Study Section Panel B Reviewer, 2005-2007

ICRF Scientific Advisory Board, 2007-

Netwellness Expert Panel: Thyroid diseases, 2006-

Search Committee, Vascular Division Chief, Department of Surgery, 2006

Search Committee, Heme-Oncology Division Director, Dept of Internal Medicine, 2007

Chair, Cancer Care Performance Improvement Committee, 2007-

Barrett Cancer Center Operations Committee, 2007-

Chair, Cancer Center Medical Directors Committee, 2007-

UC/Humana Physician Leadership Program, 2007-2008

Clinical Care Administration:

Principal Investigator, Sunbelt Melanoma Trial, University of Cincinnati site, 1997-2004

Multidisciplinary Melanoma Core Faculty, 1998-2006

Principal Investigator, ACOS-OG Melanoma Limb Perfusion Trial Z020, University of Cincinnati site, 2000-2004

Surgical Principal Investigator, SWOG Melacine Adjuvant Trial for HLA A2/C3 Patients, 2003-2004

Melanoma Care Consortium, National Faculty, 2004-2006

Principal Investigator, Multicenter Selective Lymphadenectomy Trial-II, UC Site, 2005-2006

Editorial Activities:

Ad hoc reviewer, Cancer Research, Cancer, Annals of Surgical Oncology, Journal of Surgical Oncology, Journal of Clinical Oncology, 1999-2006

 

Research Grants:

Howard Hughes Medical Institute
Research Scholars Program

1986-1987

 

National Research Service Award
NIH Postdoctoral Training Fellowship (T32 CA09672)
Surgical Oncology

1991-1993

American Cancer Society
Postdoctoral Training Grant #PRTF-148
T Cell Receptor Vb Chain Usage in Anti-Tumor Effector T Cells

1992-1993

 

American Cancer Society

Institutional Grant #189

Cytokine/tumor vaccine-primed draining lymph node cells: Phenotype and activity after ex-vivo activation and expansion

PI: Sussman, JJ

1997-1998

Faculty Development Award

Immunotherapy External Site Visits

PI: Sussman, JJ

1998-1999

University Research Council Grant

Tumor Induced Immunosuppression in a Poorly Immunogenic Murine Melanoma

PI: Sussman, JJ

1998-1999

Central Surgical Association

Modulation of the Type 1 / Type 2 Immune Response to Improve Cancer Immunotherapy

PI: Sussman, JJ

1999-2000

Ohio Cancer Research Associates

Immune Response Modulation Improves Cancer Immunotherapy

PI: Sussman, JJ

1999-2001

VA VISN 10 Research Initiative Program

Immune Response Modulation to Improve Cancer Immune therapy

PI: Sussman, JJ

1999-2000

VA Advanced Career Development Award

Immune Response Modulation to Improve Cancer Immune therapy

PI: Sussman, JJ

2000-2003

Ruth Lyons / Cancer Challenge Program

Establishment of a Cellular Adoptive Immunotherapy Laboratory

PI: Sussman, JJ and Lowy, AM

2000-2001

Dean’s Discovery Fund Award

Establishment of a Cellular Adoptive Immunotherapy Laboratory

PI: Sussman, JJ

2004-2005

 

Presentations (Selected):

"Stimulation of murine T cell hybridomas with anti-Thy-1 monoclonal antibodies results in IL-2 production and inhibition of growth" -- Federation of American Societies for Experimental Biology, Washington DC, 1987, poster presentation.

"Systemic transfer of superantigen activated T cells leads to the regression of experimental brain tumors in mice" -- American College of Surgeons, Clinical Congress, Surgical Forum, San Francisco, CA, 1993.

"Systemic T cell adoptive immunotherapy of experimental brain tumors" -- American College of Surgeons, Michigan Chapter Resident-Surgeons Day, Grand Rapids, MI, 1993.

"Eradication of murine intracranial tumors by systemic T cell immunotherapy" -- Immunotherapy of Cancer Keystone Symposia, Taos, NM, 1993.

"Systemic T cell adoptive immunotherapy of experimental brain tumors" -- American Association of Immunologists, Denver, CO, 1993.

"Short-term continuous infusion of IUDR produces potentially radiosensitizing incorporation in soft tissue sarcomas" -- American Society of Clinical Oncology, Orlando, FL, 1993.

"Pregnancy and Cancer" -- M.D. Anderson Grand Rounds, Houston, TX, 1996.

"Immunotherapy and Melanoma" -- M.D. Anderson Grand Rounds, Houston, TX, 1997.

"Lymphatic Mapping and Sentinel Node Identification in Melanoma and Breast Cancer" -- Medical Oncology Grand Rounds, 9/1997; Radiation Oncology Grand Rounds 8/1998 Cincinnati, OH.

"Breast Cancer Lymphatic Mapping and Sentinel Node Identification " -- Christ Hospital Winter Conference, St. Thomas, USVI, 2/1998.

"Melanoma Lymphatic Mapping and Sentinel Node Identification " -- Schering sponsored Cincinnati, OH, Community Physician Outreach, 2/98, 4/98, 5/98, 8/98, 4/99.

“Advances in Melanoma” -- General Surgery Grand Rounds 3/1998, Dermatology Grand Rounds, 7/1998, Head & Neck Surgery Grand Rounds, 12/1998, and Plastic Surgery Grand Rounds, 2/1999, Cincinnati, OH.

“Childhood Melanoma” -- Tumor board, 4/1998, Children’s Hospital, University of Cincinnati, OH, slide presentation.

“Moles and Melanoma” -- Public Education: Radio stations WVXU, 8/1998; WKFI, 8/1998; Wellness Community, 9/1998, Cincinnati, OH.

Moderator for “Lymphatic Mapping for Breast Cancer and Melanoma,” Satellite Course, 1998 Cincinnati, OH.

Guest Faculty, Lymphatic Mapping and Sentinel Node Biopsy Course, 12/10/1998, 6/3/1999, Institute for Research and Education, Minneapolis, MN.

“Hyperthermic Isolated Limb Perfusion,” Good Samaritan Hospital, Surgery Grand Rounds, 10/1999, Cincinnati, OH.

“Nodal Management”-- Melanoma Update for the Millennium, 10/1999, Cincinnati, OH.

“Sun Protection/Childhood Melanoma” Public Education TV station WLW 5/2000, Cincinnati, OH.

“Hyperthermic Chemoperfusion” Good Samaritan Grand Rounds, 12/8/2000, Cincinnati, OH.

“Advances in Melanoma Management” Medical Oncology Grand Rounds, 11/3/2000, Cincinnati, OH.

“Advances in Melanoma Management” Plastic Surgery Grand Rounds, 8/8/2001, Cincinnati, OH.

“Node Management in Melanoma” General Surgery Grand Rounds, 3/6/2002, Cincinnati, OH.

Breast Sentinel Node Workshop, St Lukes Hospital, 4/5/2002

 “Immunotherapy of Cancer” General Surgery Grand Rounds, 1/2003, Cincinnati, OH.

 

 “Diagnosis and Treatment Benign Liver Masses”  Primary Care Update on Cancer Seminar, 5/2004. Cincinnati, OH.

 

 “Breast Cancer Update”  VA Women’s Health Care Update, 11/2004. Columbus, OH.

Melanoma Awareness Program, 2002-2007, Cincinnati, OH; Dayton OH, Kettering OH, Fort Wayne, IN., Troy, OH.

 

 “Update Parathyroid Surgery”, 10/2006, UCS Symposium, Mason, OH.

 

 “Pancreatic Cancer Surgery-Is there a Standard?” 2nd Annual Esophogeal/Pancreatic Cancer Symposium, 11/2006, Cincinnati, OH. 

 


BIBLIOGRAPHY

Published Articles:

1.  Sussman JJ, Bonifacino JS, Lippincott-Schwartz J, Weisman AM, Saito T, Klausner RD, Ashwell JD:  Failure to Synthesize the T Cell CD3-Zeta Chain: Structure and Function of a Partial T Cell Receptor Complex.  Cell.  52(1):85-95, 1988.

2.  Sussman JJ, Mercep M, Saito T, Germain RN, Bonvini E, Ashwell JD:  Dissociation of Phosphoinositide Hydrolysis and Ca2+ Fluxes from the Biological Responses of a T Cell Hybridoma.  Nature.  334(6183):625-8, 1988.

3.  Sussman JJ, Saito T, Shevach EM, Germain RN, Ashwell JD:  Thy-1- and Ly-6-Mediated Lymphokine Production and Growth Inhibition of a T Cell Hybridoma Require Co-Expression of the T Cell Antigen Receptor Complex.  J. Immunol.  140(8):2520-6, 1988.

4.  Bonifacino JS, Mercep M, Sussman JJ, Klausner RD, Ashwell JD:  The T-Cell Antigen Receptor: A Complex Signal-Transducing Molecule. Int Symp Princess Takamatsu Cancer Res Fund.  19:87-104, 1988.

5.  Saito T, Sussman JJ, Ashwell JD, Germain RN:  Marked Differences in the Efficiency of Expression of Distinct Alpha Beta T Cell Receptor Heterodimers.  J. Immunol.  143(10):3379-84, 1989. [erratum: 144(7):2848, 1990]

6.  Volarevic S, Burns CM, Sussman JJ, Ashwell JD:  Intimate Association of Thy-1 and the T Cell Antigen Receptor with the CD45 Tyrosine Phosphatase.  Proc. Natl. Acad. Sci. USA.  87(18):7085-9, 1990.

7.  Shu S, Sussman JJ, Chang AE:  In Vivo Antitumor Efficacy of Tumor-Draining Lymph Node Cells Activated with Nonspecific T-Cell Reagents.  J. Immunother.  14:279-85, 1993.

8.  Sussman JJ, Chang AE, Shu S:  Systemic Transfer of Superantigen-Activated T Cells Leads to the Regression of Experimental Brain Tumors in Mice.  Surgical Forum  XLIV:477-9, 1993.

9.  Shu S, Krinock RA, Matsumura T, Sussman JJ, Fox BA, Chang AE, Terman DS:  Stimulation of Tumor-Draining Lymph Node Cells with Superantigenic Staphylococcal Toxins Leads to the Generation of Tumor-Specific Effector T Cells.  J. Immunol. 152:1277-88, 1994.

10.  Matsumura T, Sussman JJ, Krinock RA, Chang AE, Shu S:  Characteristics and In Vivo Homing of Long-Term T Cell Lines and Clones Derived from Tumor-Draining Lymph Nodes.  Cancer Res. 54:2744-50, 1994.

11.   Sussman JJ, Shu S, Sondak VK, Chang AE:  Activation of T Lymphocytes for the Adoptive Immunotherapy of Cancer.  Ann. Surg. Oncol. 1(4):296-306, 1994.

12.  Wahl WL, Sussman JJ, Shu S, Chang AE:  Adoptive Immunotherapy of Murine Intracerebral Tumors with Anti-CD3/IL-2 Activated Tumor-Draining Lymph Node Cells.  J. Immunother.  13:242-250, 1994.

13.  Robertson JM, Sondak VK, Weiss SA, Sussman JJ, Chang AE, Lawrence TS:  Preoperative Radiation Therapy and Iododeoxyuridine for Large Retroperitoneal Sarcomas.  Int. J. Rad. Oncol. Biol. and Phys. 31:87-92, 1995.

14.  Sussman JJ, Wahl WL, Chang AE, Shu S:  Unique Characteristics Associated with Systemic Adoptive Immunotherapy of Experimental Intracerebral Tumors. J. Immunother. 18(1):35-44, 1995.

15.  Sondak VK, Robertson JM, Sussman JJ, Saran PA, Chang AE, Lawrence TS:  Preoperative Iododeoxyuridine and Radiation for Large Soft Tissue Sarcomas: Clinical Results with Five-year Follow-up. Annals of Surgical Oncology, 5(2): 106-112. 1998.

16.  Heaton KM, Sussman JJ, Gershenwald JE, Lee JE, Reintgen DS, Mansfield PF, Ross MI:  Surgical Margins and Prognostic Factors in Thick (>4mm) Primary Melanoma. Annals of Surgical Oncology, 5(2): 322-327. 1998.

17.   Anderson CM, Buzaid AC, Sussman JJ, Lee J, Ali-Osman F, Braunschweiger PG, Plager, C, Bedekian A, Papadopuolos n, Eton O, Legha S, Grimm EA,:  Nitric Oxide and Neopterin Levels and clinical Response in Stage III Melanoma Patients Receiving Concurrent Biochemotherapy. Melanoma Research, 8(2):149-55. 1998

18.  Dackiw APB, Sussman JJ, Stanford P, Hoff A, Gagel RF, Evans DB, Lee JE:  Relative Contributions of Technitium 99M Sestamibi Scintigraphy, Intraoperative Gamma Probe Detection and the Rapid PTH Assay to the Surgical Management of Hyperparathyroidism. Archives of Surgery, 135(5):550-5. 2000.

19.  Sarnaik AA, Sussman JJ, Ahmad SA, Lowy AM.  Technology of Intraperitoneal Chemotherapy Administration: A Survey of Techniques with a Review of Morbidity and Mortality.  Surgical Oncology Clinics of North America.  WB Saunders, vol 12 (3), pp 849-864, 2003

20.   Ahmad SA, Kim J, Sussman JJ, Soldano DA, Pennington LJ, James LE, Lowy AM. Reduced morbidity following cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion.  Annals of Surgical Oncology,11(4): 387-392. 2004.

21.   McMasters KM, Noyes RD, Reintgen DS, Goydos JS, Beitsch PD, Davidson BS, Sussman JJ, Gershenwald JE, Ross MI; Sunbelt Melanoma Trial. Lessons learned from the Sunbelt Melanoma Trial.  J Surg Oncol. 2004 Jul 1;86(4):212-23. 

22.  Sussman, JJ, Parihar R, Winstead K, Finkelman, FD.  Prolonged Culture of Vaccine Primed Lymphocytes Results in Decreased Anti-Tumor Killing and Change in Cytokine Secretion.  Cancer Research, 64(24): 9124-9130 2004.

23.  Lee PK, Sussman JJ  53 year old Melanoma on Back.  Melanoma Care Options, Volume 6, July 2005.

24.   Hershko DD, Robb BW, Lowy AM, Ahmad SA, Ramadas GH, Pennington LJ, Soldano DA, Sussman JJ.  High Incidence of Positive Sentinel Lymph Nodes Identified in Thin Melanoma Patients.  J Surg Oncol.  93(4):279-85, 2006.

25.  Scoggins CR, Ross MI, Reintgen DS, Noyes D, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Davidson BS, Sussman JJ, Edwards MJ, Martin CG, Conrad A, Albrecht J, Mc,asters KM.  A Prospective Multi-Institutional Study of Reverse Transcriptase Polymerase Reaction for Molecular Staging of Melanoma  J Clin Oncol, 24(18):2849-57, 2006.

26.  Cornett WR, Fraker DL, Ross MI, Briele HA, Bodie AW, Noyes RD, Sussman JJ, McCall JE, Herndon JE, Tyler DS.  Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020.  J Clin Oncol Sept. 24(25): 4196-201, 2006.

27.  Hugo E, Brandenbourgh T, Comstock C, Gersin K, Sussman JJ, Ben-Jonathan N.  LS14: A Novel Human Adipocyte Cell Line that Produces Prolactin. Endocrinology. Jan;147(1):306-13,  2006.

28.  Scoggins CR, Ross MI, Reintgen DS, Noyes D, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Sussman JJ, Edwards MJ, Chagpar AB, Martin RCG, Stromberg AJ, Hagendoorn L, McMasters KM  Gender Related Differences in Outcome for Melanoma Patients. Ann Surg 243:693-700, 2006.

29.  Mammen JM, James LE, Molloy M, Williams A, Wray CJ, Sussman JJ.  The relationship of lymph node dissection and colon cancer survival in the Veterans Affairs Central Cancer Registry.. Am J Surg. 194(3):349-54, 2007

30.  Mammem, JMV, James LE, Ahmad, S, Sussman JJ, The Relationship of Lymph NodeStatus and Extrahepatic Cholagiocarcinoma Survival in the Veterans Affairs Central Cancer Registry, submitted Am J Surgery, 2007.

31.  Nair R, McIntyre B, Lowy AM, Sussman JJ, Matthews JB, Ahmad SA.  A novel technique for the management of refractory pancreatic fistula  in press Sugery  2007.

Chapters:

1.   DeLucia, A, Magee, JC, Shanley, CJ, Simeone, DM, Sussman JJ, Wahl, WL. Review for Surgery: Scientific Principles and Practice.  Greenfield, LJ, Mulholland, MW, Oldham, KT, Zelenock, GB (Eds.) J.B.Lippincott, Philadelphia, 1993.

2.  Sussman JJ, Ellis, LM.  Current Therapy for Hepatic Metastases, In: Current Hepatology; Volume 17. Gitnick, G (ed) Mosby, Chicago, p. 195-220, 1997.

3.  Gershenwald JE, Sussman JJ, Lee JE. Melanoma (chapter 3), In: The M. D. Anderson Surgical Oncology Handbook, second edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 1999.

4.  Bold RJ, Sussman JJ, Tyler DS. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia (chapter 14), In: The M. D. Anderson Surgical Oncology Handbook, second edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 1999.

5.  Sussman JJ. Adoptive Cellular Therapy for Cancer, In: Current Perspectives in Cellular Therapy 2002.  Szczepirkowski, ZM and Snyder, EL (Eds.), American Association of Blood Banks, 2001.

6.  Barnett CC, , Sussman JJ, Gershenwald JE. Melanoma (chapter 3), In: The M. D. Anderson Surgical Oncology Handbook, Third edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 2003.

7.  Lenert JT, Bold RJ, Sussman JJ, Tyler DS. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia (chapter 14), In: The M. D. Anderson Surgical Oncology Handbook, Third edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 2003.

8.  Sussman JJ, Surgical Emergencies in the Cancer Patient.  Surgery: Basic Science and Clinical Evidence, 2nd edition, ed. JA Norton, et al, Springer-Verlag (submitted)

9.  Lenert JT, Bold RJ, Sussman JJ, Tyler DS. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia (chapter 14), In: The M. D. Anderson Surgical Oncology Handbook, Fourth edition. Feig, BW, Berger, DH and Fuhrman, GM (Eds.), Lippincott Williams & Wilkins, Philadelphia, 2006.

10.  Sussman JJ, Surgical Emergencies in the Cancer Patient.  Essentials of Surgical Oncology.  Editors: Sondak VK, Sabel M, and Sussman JJ.  Elsevier Science/MOSBY, Philidelphia, 2007

11.  Sussman JJ, Surgery for Advanced Cancer.  Essentials of Surgical Oncology.  Editors: Sondak VK, Sabel M, and Sussman JJ.  Elsevier Science/MOSBY, Philidelphia, 2007

Books:

1.  Essentials of Surgical Oncology.  Editors: Sondak VK, Sabel M, and Sussman JJ.  Elsevier Science/MOSBY, Philadelphia, 2007.