Janice Frederick Rafferty, M.D.
Professor of Surgery
Chief, Division of Colon and Rectal Surgery
Certification:
American Board of Surgery #41393; 6/96
Recertification October 2004
American Board of Colon & Rectal Surgery #1411; 9/97
Recertification June 2006
Advanced Trauma Life Support 12/2000
Clinical and Academic Office address:
2123 Auburn Avenue, Suite 524
Cincinnati, Ohio 45219
Phone: (513) 929-0104
Fax (513)-929-4369
Janice.rafferty@uc.edu
PRE-MEDICAL EDUCATION
1981-1984 Miami University of Ohio, Oxford, Ohio
B.A. - Cum laude
MEDICAL EDUCATION
1984-1988 The Ohio State University College of Medicine, Columbus, Ohio
M.D. Degree
POST-GRADUATE TRAINING
1988-1994 General Surgical Residency
University of Cincinnati Hospital
Cincinnati, Ohio
1994-1995 Chief Surgical Resident
University of Cincinnati Hospital
Cincinnati, Ohio
1995-1996 Colon and Rectal Surgery Fellowship
Jewish Hospital at Washington University Medical Center
St. Louis, Missouri
POSITIONS/APPOINTMENTS
1996 Assistant Professor of Surgery, Department of Surgery , University of Cincinnati College of Medicine.
1996 Attending Surgeon - University of Cincinnati Hospital
1996 Attending Surgeon - The Christ Hospital, Cincinnati, Ohio
1996 Attending Surgeon - The Jewish Hospital, Cincinnati, Ohio
1996 Consulting Surgeon - VA Medical Center, Cincinnati, Ohio
1997 Consulting Surgeon - The Children's Hospital Medical Center, Cincinnati, Ohio
1998 Consulting Surgeon - Good Samaritan Hospital, Cincinnati, Ohio
2000 Chief, Division of Colon and Rectal Surgery, University of Cincinnati Department of Surgery
2004 Associate Professor of Surgery, Department of Surgery, University of Cincinnati College of Medicine
RESEARCH EXPERIENCE
1985 Research Assistant, Ohio State University Division of Cardiology, Columbus, Ohio
1987-1988 Primary Investigator, Ohio State University Division of Cardiothoracic
Surgery, Columbus, Ohio
"Comparative study of peripheral vascular effects of amrinone, sodium
nitroprusside and nitroglycerin in the total artificial heart calf"
1990-1992 Research Fellow, University of Cincinnati College
of Medicine, Cincinnati, Ohio
"Studies on the metabolic effects of sepsis" under the direction
of Dr. Josef E. Fischer and Dr. Per-Olof Hasselgren
1991-1992 ECMO Fellow, Children's Hospital Medical Center, Department of Pediatric Surgery, Cincinnati, Ohio
CLINICAL RESEARCH PROJECTS
Principal Investigator, IRB-approved Cincinnati study arm of multicenter Cancer Biomarker Study MTG-015 (Version 2): “Colon Cancer Tissue Protocol: The Discovery and Evaluation of Biomarkers for the Prediction, Diagnosis and Management of Disease – A Pilot Trial.” The Carl & Edyth Lindner Center for Research and Education at The Christ Hospital, 2009.
Principal Investigator, Cincinnati study arm of multicenter trial – IRB#08-10: “Intergroup Randomized Phase III Study of Postoperative Oxaliplatin, 5-Fluorouracil and Leucovorin vs Oxaliplatin, 5-Fluorouracil, Leucovorin and Bevacizumab for Patients with Stage II or III Rectal Cancer Receiving Pre-operative Chemoradiation.” The Christ Hospital, Cincinnati, Ohio, 2008.
Principal Investigator, Cincinnati study arm of multicenter trial – IRB#07-84: “A Randomized, Controlled, Phase 3 Study of Gentamicin-Collagen Sponge (Collatamp G) in General Surgical Subjects at Higher Risk for Surgical Wound Infection.” The Christ Hospital, Cincinnati, Ohio, 2008.
Principal Investigator, Cincinnati study arm of multicenter trial – IRB#07-59: “Quality of Life and Functional Outcomes after Combined Modality Therapy for Anal Cancer: A Comparison of Conventional versus Intensity-Modulated Radiation Therapy.” The Christ Hospital, Cincinnati, Ohio, 2008.
Principal Investigator, Cincinnati study arm of multicenter trial – IRB#07-42: “Evaluation of the Outcomes of Restoring Pelvic Floor Support Using the TOPAS AMS Pelvic Floor Repair System in Women with Moderate Fecal Incontinence Symptoms.” Sponsored by American Medical Systems. The Christ Hospital, Cincinnati, Ohio, 2007.
Principal Investigator, Cincinnati study arm of multicenter trial – IRB#07-23: “Stapled Trans-Anal Rectal Resection (STARR) in the Treatment of Obstructed Defecation Syndrome (ODS) – U.S. STARR Registry.” Sponsored by Ethicon Endo-Surgery/US STARR Registry. Study completed.
Principal Investigator, Cincinnati study arm of multicenter trial – IRB#06-86: “A Phase 3, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI).” Study completed.
Principal Investigator, Cincinnati study arm of multicenter trial – IRB#07-45: “Translational Oncology: Discovery and Evaluation of Biomarkers and Pharmacogenomics for the Diagnosis and Personalized Management of the Colon Cancer Patient” [Colon Cancer Biomarker Study MTG-015: Colon Cancer Tissue and Adjacent Normal Tissue; Moss TJ, Protocol Chairman]. Study completed.
Principal Investigator, Cincinnati study arm of multicenter trial – “A Study to Determine the Nitroglycerin Ointment Dose and Dosing Interval that Best Promote the Complete Healing of Chronic Anal Fissures.” Sponsored by Cellergy Pharmaceuticals. Study completed.
Principal Investigator, Cincinnati study arm of multicenter trial – “A Multicenter, Phase III, Double-Blind, Placebo-Controlled, Parallel Study of ADL 8-2698 in Opioid Induced Postoperative Bowel Dysfunction/Postoperative Ileus.” Sponsored by Adolor. Study completed.
Principal Investigator, Cincinnati study arm of multicenter trial – “A Prospective, Multicenter, Double-Blind, Randomized, Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of a Single Dose of Ertapenem Sodium (MK-0826) versus Cefotetan for the Prophylaxis of Surgical Site Infection Following Elective Colorectal Surgery.” Sponsored by Merck. Study completed.
Principal Investigator, Cincinnati study arm of multicenter trial – “Evaluation of the Safety and Effectiveness of Seprafilm Adhesion Barrier in Limiting Postoperative Adhesion Formation to Serosal Tissue (Abdominal Surgery).” Sponsored by Genzyme. Study completed.
ORGANIZATIONS
American College of Surgeons – Fellow (1999)
American Society of Colon and Rectal Surgeons – Fellow (1999)
Association of Women Surgeons
Central Surgical Association
Cincinnati Academy of Medicine
Cincinnati Surgical Society
Crohn’s & Colitis Foundation of America/Cincinnati Chapter
Ohio Valley Society of Colon and Rectal Surgeons
ADMINISTRATIVE RESPONSIBILTIES
American Board of Colon and Rectal Surgery – Senior Examiner
American Society of Colon and Rectal Surgeons – Executive Council (2008-2011)
American Society of Colon and Rectal Surgeons – Vice Chair, Standards Committee (2008-present)
Director of Surgical Education, The Christ Hospital (2000-2005; 2008-present)
The Christ Hospital Graduate Medical Education Committee (2008-present)
Chair for Postgraduate Course PG22 (Benign Colon Disease) at the American College of Surgeons’ 2008 Clinical Congress, San Francisco (2008).
University of Cincinnati Foundation Board of Governors (2006-present)
University of Cincinnati College of Medicine Reappointment, Promotion & Tenure (RPT) Committee (2007-present)
Cincinnati Academy of Medicine – Advisory Council (2006-2008)
Cincinnati Surgical Society – President (2008-present)
American Society of Colon and Rectal Surgeons Program Committee Co-Chair (2005-2006)
Representative to the Ohio State Medical Association from Ohio Valley Society of Colon and Rectal Surgeons (2002-2003)
Local program director, Ohio Valley Society of Colon and Rectal Surgeons annual meeting, Cincinnati, OH (2003)
United Ostomy Association, Cincinnati Chapter – Medical Advisor
AWARDS AND HONORS
Samuel J. Roessler Research Scholarship, Ohio State University, 1986-1988.
Ohio State University Landacre Society Research Forum Award, 1988.
Resident Research Award, University of Cincinnati Department of Surgery, 1992.
Faculty Development Award, University of Cincinnati, 1998.
Health Alliance Leadership program, Cincinnati, 1998.
Young Clinician Award, American Society of Colon & Rectal Surgeons, 1998.
Cincinnati Business Courier “Health Care Hero” Award, Provider Category, 2000.
Honored for Contributions to Colorectal Cancer Care in Cincinnati area, Speaking of Women’s Health Conference, 2001.
Member of “Consultants Corner” panel, Ohio Valley Society of Colon and Rectal Surgeons annual meeting, Cincinnati, OH, April 2003.
Included among Cincinnati Magazine's “Top Doc” list (chosen by community physicians), 2003, 2007 (top vote getter), and 2008.
American College of Surgeons “Surgeons as Leaders” course, Chicago, IL, 2007.
REVIEWER
Annals of Surgery
Diseases of Colon & Rectum
International Journal of Urogynecology
Journal of Surgical Oncology
World Journal of Surgery
EDITOR
Guest Editor: Polyps and Polyposis Coli, Clinics in Colon and Rectal Surgery 2008; 21(4):233-318
COMMITTEES
American Society of Colon and Rectal Surgeons Committee on Standards (Vice-Chair, 2008-2010)
The Christ Hospital Committee on Graduate Medical Education
The Christ Hospital Infection Control Committee
University of Cincinnati Residency Committee
INVITED LOCAL AND REGIONAL PRESENTATIONS
“Diagnosis and Management of Pelvic Floor Abnormalities.” University of Cincinnati Department of Surgery Grand Rounds, Cincinnati, OH, 1996.
“Surgical Management of Inflammatory Bowel Disease.” Crohn’s and Colitis Foundation, Cincinnati Chapter, Cincinnati, OH, 1996.
“Diagnosis and Management of Pelvic Floor Abnormalities.” The Christ Hospital Department of Medicine Grand Rounds, Cincinnati, OH, 1999.
“Local Treatment of Rectal Cancer.” Good Samaritan Hospital Department of Surgery Grand Rounds, Cincinnati, OH, 1998.
“Surgical Treatment of Inflammatory Bowel Disease.” University of Cincinnati Department of Surgery Grand Rounds, Cincinnati, OH, 2000.
“Evaluation and Treatment of Lower Gastrointestinal Bleeding.” Good Samaritan Hospital Department of Surgery Grand Rounds, Cincinnati, OH, 2001.
“Current Treatment of Colorectal Cancer.” University of Cincinnati Resident Educational Conference, Cincinnati, OH, 2002.
“Diagnosis & Management of Rectal Neoplasms.” University of Cincinnati Department of Medicine, Division of Hematology-Oncology Grand Rounds, Cincinnati, OH, 2003.
“Surgical Management of Hemorrhoidal Disease.” Grant Medical Center, Department of Surgery Grand Rounds, Columbus, OH, 2003.
“Current Concepts in Surgery for Inflammatory Bowel Disease.” Crohn’s and Colitis Foundation, Dayton Chapter, Dayton, OH, 2003.
Keynote Speaker. Hamilton County First Annual Colorectal Cancer Summit (sponsored by the American Cancer Society, Ohio Division, and the Ohio Department of Health, Cancer Program), Cincinnati, OH, 2005.
“Innovations in Colorectal Surgery: Laparoscopy and Anorectal Procedures.” ‘Speaking of Women's Health’ Forum, Cincinnati, OH, 2005.
“How Can We Improve Patient-Provider Communication to Overcome Barriers Related to Culture and Diversity?” Ohio statewide conference, Dialogue for Action: Current Concepts in CRC Screening and Control, Columbus, OH, 2005.
“What’s New in the Care of Colorectal Disease.” The Christ Hospital Department of Medicine Grand Rounds, Cincinnati, OH, 2006.
“Fecal Incontinence.” ‘Let’s Talk, Ladies’ – Community education event sponsored by The Christ Hospital, Cincinnati, OH, 2006.
“’Oh Crap’ and other Conversation Stoppers.” Women’s Health Day, Kenwood Country Club, Cincinnati, OH, 2006.
“Surgical Indications in IBD.” University of Cincinnati Department of Surgery Resident Basic Science Lecture, Cincinnati, OH, 2007.
“Prevention of Surgical Site Infection.” Allentown PA Surgical Society, Allentown, PA, 2007.
“Diagnosis and Surgical Management of Enterocutaneous Fistulas.” Ohio Valley Society of Colon and Rectal Surgeons, Louisville, KY, 2007.
“Evaluation and Treatment of Constipation and Incontinence.” Cincinnati Children’s Hospital, Department of Pediatric Surgery Grand Rounds, Cincinnati, OH, 2007.
Keynote Speaker. “Current Trends in the Management of Colorectal Cancer”
12th Annual Lewis A. Schmidt, MD Memorial Cancer Symposium, Holzer Medical Center, Gallipolis, OH, 2008.
“The Surgeon's Role in Managing Inflammatory Bowel Disease.” Inflammatory Bowel Disease Education Day, sponsored by the Crohn’s & Colitis Foundation of America and the Schubert-Martin Inflammatory Bowel Disease Center at Cincinnati Children's Hospital Medical Center, Mason, OH, 2009.
INVITED NATIONAL AND INTERNATIONAL PRESENTATIONS
“Etiology of GI Bleeding: Are We Certain?” American College of Surgeons Postgraduate Course in Colon and Rectal Surgery, San Francisco, CA, 1999.
“Pregnancy and Inflammatory Bowel Disease.” American Gastroenterological Association Annual Meeting, San Diego, CA, 2000.
“Influence of Stoma on Sexual Function in Women.” United Ostomy Association National Meeting, St. Louis, MO, 2000.
“Surgical Treatment of Constipation.” American College of Surgeons Postgraduate Course in Colon and Rectal Surgery, Chicago, IL, 2000.
“Ask the Doctor.” United Ostomy Association National Conference, Louisville, KY, 2004.
“Basic J Pouch.” United Ostomy Association National Conference, Louisville, KY, 2004.
“Internal Rectal Intussusception and Solitary Rectal Ulcer Syndrome.” Clinical Congress of the American College of Surgeons, Postgraduate Course on Colon and Rectal Surgery: Benign Colorectal Disease, New Orleans, LA, 2004.
“Use of Prosthetic Biomesh in Pelvic Floor Reconstruction.” American Society of Colon and Rectal Surgeons Annual Meeting, St. Louis, MO, 2007.
“Complications in Diverticulitis.” American Society of Colon and Rectal Surgeons Annual Meeting, St. Louis, MO, 2007.
“Perioperative Complications.” American Society of Colon and Rectal Surgeons Annual Meeting, St. Louis, MO, 2007.
“Posterior Compartment Dysfunction.” International Urogynecology Association, Cancun, Mexico, 2007.
“Ask the Colorectal Surgeon” United Ostomy Association National Conference, Lincolnshire, IL, 2007.
“What’s new in Proctology?” OSMA, May 5, 2008.
“Is Surveillance for Recurrent Anal Cancer Beneficial After Complete Tumor Regression?” ASCRS podium presentation, June 9, 2008.
JOURNAL ARTICLES
Magorien RD, Frederick J, Leier CV, Unverferth DV. Influence of exercise on coronary sinus blood flow determinations. Am J Cardiol 59:659-661, 1987.
Zamir O, James JH, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. The effects of endotoxemia and cytokines on amino acid transport in skeletal muscle and the possible role of glucocorticoids. Surg Forum 42:101, 1991.
Zamir O, Hasselgren PO, Kunkel SL, Frederick JA, Higashiguchi T, Fischer JE. Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis. Arch Surg 127:170-174, 1992.
Zamir O, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. Effect of sepsis or cytokine administration on release of gut peptides. Am J Surg 163:181-185, 1992.
Stallion A, Frederick J, Milesky D, Warner B, Ryckman F. Bleeding complication associated with ECMO treatment of congenital diaphragmatic hernia. In ELSO: ECMO Pump Talk, Vol 3, No. 1, Jan/April 1992.
Zamir O, Hasselgren PO, Frederick JA, Fischer JE. Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats. J Pediatric Surg 27:1399-1403, 1992.
von Allmen D, Hasselgren PO, Higashiguchi T, Frederick JA, Zamir O, Fischer JE. Increased intestinal protein synthesis during sepsis following the administration of tumor necrosis factor a (TNFa) or interleukin-1a (IL-1a). Biochemical Journal 286:585-589, 1992.
Zamir O, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. Tumor necrosis factor (TNF) and interleukin-1 (IL-1) induce muscle proteolysis through different mechanisms. Mediators of Inflammation 11:247-250, 1992.
Higashiguchi T, Frederick JA, Zamir O, Hasselgren PO, Fischer JE. Effects of glutamine on protein synthesis in isolated enterocysts from septic rats. Surg Forum 43:26-28, 1992.
Frederick JA, Hasselgren PO, Davis S, Higashiguchi T, Jacob TD, Fischer JE. Nitric oxide may upregulate in vivo hepatic protein synthesis during endotoxemia. Arch Surg 128:152-157, 1993.
Zamir O, Nussbaum MS, Ogle CK, Higashigushi T, Rafferty JF, Fischer JE. Addition of glucagon to lipid-free total parenteral nutrition reduces production of prostaglandin E2 by stimulated splenic macrophages. JPEN 17(3):226-230, 1993.
Zamir O, Nussbaum MS, Bhadra S, Subbiah R, Rafferty JF, Fischer JE. Effect of enteral feeding on hepatic steatosis induced by total parenteral nutrition. JPEN 18(1):20-25, 1994.
Rafferty JF, Noguchi Y, Fischer JE, Hasselgren PO. Sepsis in rats stimulates cellular proliferation in mucosa of the small intestine. Gastroenterology 107:121-127, 1994.
Tiao G, Rafferty JF, Ogle CK, Fischer JE, Hasselgren PO. Detrimental effect of nitric oxide synthesis inhibition during endotoxemia may be caused by high levels of TNF and IL-6. Surgery 116:332-338, 1994.
Stallion A, Rafferty JF, Warner B, et al. Myocardial calcification: a predictor of poor outcome for myocarditis treated with ECMO. J Ped Surg 29:492-494, 1994.
Stallion A, Cofer BR, Rafferty JF, Ziegler MM, Ryckman F. The significant relationship between platelet count and hemorrhagic complications on ECMO. Perfusion 9(4):265-269, 1994.
Rafferty JF. Immunonutrient effect following gunshot wound to the abdomen. J Crit Care Nutrition 3(1):36, 1995.
Rafferty JF. Pregnancy after restorative proctocolectomy. In Selected Topics in Colon and Rectal Surgery, Volume 9, 1996.
Birnbaum EH, Stamm L, Rafferty JF, Fry RD, Koder IJ, Fleshman JW. Pudendal nerve terminal motor latency influences surgical outcome in the treatment of rectal prolapse. Dis Col Rectum 39:1215-1221, 1996.
Rafferty JF, Birnbaum EH. Endocavitary radiation for rectal cancer. Seminars in Colon and Rectal Surgery 7(4):238-242, 1996.
Rafferty JF. Obtaining adequate bowel length for colorectal anastomosis. Clinics in Colon and Rectal Surgery 14:25-31, 2001.
Robb BW, Pritts TA, Gang GI, Warner BW, Seeskin CS, Stoopes MM, James LE, Rafferty JF, Azizkhan RG, Martin LW, Nussbaum MS. Quality of life in patients undergoing ileal pouch-anal anastomosis at the University of Cincinnati. Am J Surg 183:353-360, 2002.
Falcone RA, Knott AW, Rafferty JF, Warner BW. Sacrococcygeal teratoma and teratocarcinoma. Seminars in Colon and Rectal Surgery 15(1):19-25, 2004.
Anthony T, Simmang C, Hyman N, Rafferty JF, et al. Practice parameters for the surveillance and follow-up of patients with colon and rectal cancer. Dis Col Rectum 47:807-817, 2004.
Othchy D, Hyman NH, Simmang C, Anthony T, Buie DW, Rafferty JF et al. Practice parameters for colon cancer. Dis Col Rectum 47:1269-1284, 2004.
Orsay C, Rakinic J, Rafferty JF, et al. Practice parameters for the management of anal fissures. Dis Col Rectum 47:2003-2007, 2004.
Rafferty JF, Shellito P, Hyman NH, Buie WD. Practice parameters for sigmoid diverticulitis. Dis Col Rectum 49:939-944, 2006.
BOOK CHAPTERS
Frederick J (Contributing Author). The Mont Reid Handbook, The University of Cincinnati Surgical Manual, 2nd Ed. Chicago: Year Book, 1992.
Frederick J, Fischer J. Hepatic failure. In Current Practice of Surgery (Copeland EM, Levine BA, eds). New York: Churchill Livingstone, 1992.
Rafferty JF (Contributing Author). The Mont Reid Handbook, The University of Cincinnati Surgical Manual, 3rd Ed. Chicago: Year Book, 1994.
Rafferty JF, Kodner IJ. Abdominoperineal resection (the Miles operation). In: Mastery of Surgery, 4th Ed. (Baker RJ, Fischer, JE, eds). Philadelphia: Lippincott Williams & Wilkins, 2000.
Rafferty JF. Rectovaginal fistula. In: Urogynecology and Reconstructive Pelvic Surgery, 2nd Ed. (Walters MD, Karram MM, eds). St Louis: Mosby, 1999.
Rafferty JF. Obtaining adequate bowel length for colorectal anastomosis. In: Clinics in Colon and Rectal Surgery, Vol. 14 (Beck DE, ed). New York: Thieme Medical Publishers, 2001.
Rafferty JF, Kodner IJ. Abdominoperineal resection (the Miles operation). In: Mastery of Surgery, 5th Ed. (Fischer, JE, Bland KI, eds). Philadelphia: Lippincott Williams & Wilkins, 2006.
Rafferty JF. Solitary rectal ulcer syndrome. In: Current Surgical Therapy, 9th Ed. (Cameron JL, ed). Philadelphia: Elsevier Mosby, 2008.
EXPERT PHYSICIAN COLUMNS
“Ask an Expert” column in Colorectal Diseases section on NetWellness website (http://www.netwellness.org/healthtopics/colorectal).
Quarterly column ("Ask Dr. Rafferty”) answering patient questions in The Phoenix magazine, the official publication of the United Ostomy Associations of America, Inc. Published four times a year (March, June, September, December).
Updated 03/31/09